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24 Extracellular vesicles (EVs) have attracted considerable attention because of their capacity for carrying proteins, lipids, and nucleic acids and transferring their cargo to recipient cells

The second main aim of this study was to determine whether mitochondrial transplantation could improve bioenergetic parameters in a cellular model of tauopathy that overexpresses the P301L-tau mutation in the MAPT gene [36]

[DOI] [PMC free article] [PubMed] [Google Scholar] 479

The content of melanin in melanocytes was increased by maclurin in a dose-dependent manner, by a mechanism involving the activation of the cAMP/PKA/CREB signaling pathway, which in turn increased tyrosinase, MITF and their downstream TRP-1 and Trp-2 protein content, while also involving the activation of p38 MAPK and p44/42 MAPK pathways

Additionally, the molecule is particularly well conserved within the Caucasoid population, exhibiting limited genetic polymorphisms

Expedites functional recovery after sciatic nerve crush injury in mice
