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There may have been differences in the intracellular iron concentration between PANC-1 and HT-29, which may have caused the differences observed in their sensitivity to the treatment

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GS is responsible for triggering the reaction that synthesizes glutamine from ammonium ion (NH 4+ ), and glutamate through ATP consumption, whereas GLS is responsible for glutamine hydrolysis, which converts it into glutamate and NH 4+ again [22,23] (Figure 1)

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One possible explanation of these results is that oral GSH undergoes partial hydrolysis and oxidation during the digestive process

Although our study focused on alkaline stress, the underlying mechanisms of EBRs protective effects are similar to those observed in studies on other abiotic stresses