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Under normal cellular conditions, Keap1 tethers Nrf2 in the cytoplasm (the region of the cell outside the nucleus), where it can be tagged and delivered for degradation

subsequently reported 11 cases of acquired 5-oxoprolinemia metabolic acidosis in patients ingesting acetaminophen (10)

Foster AE, Okur FV, Biagi E, Lu A, Dotti G, Yvon E, Savoldo B, Carrum G, Andreeff M , Goodell MA, Heslop HE, Brenner MK

This inhibits osteoclast proliferation, differentiation, and bone resorption, raises bone mass, and may contribute to the prevention of OP (219)

Belinostat in patients with relapsed or refractory peripheral T-cell lymphoma: results of the pivotal phase II BELIEF (CLN-19) study

It is worth mentioning that TLR4 signaling induction necessitates the delivery of TLR4 to PIP 2 -rich domains of the plasma membrane (Kagan and Medzhitov, 2006)