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In consequence, acylcarnitines constitute an appreciable component of the tissue carnitine pool, and tissue and plasma concentrations of carnitine and acylcarnitines are together maintained within relatively narrow limits by a variety of mechanisms, which influence in turn innumerable aspects of carbohydrate and lipid metabolism, including the regulation of insulin secretion by pancreatic -cells and the determination of tissue insulin sensitivity

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Moreover, Zhou and Yang performed a meta-analysis investigating the pooled effect of L-carnitine supplementation on improving malnutrition in patients on maintenance hemodialysis (MHD)

The mitochondrial pool of acetyl-CoA is spatially distinct from acetyl-CoA found in the nucleus and cytosol due to the inability of acetyl-CoA to cross the inner mitochondrial membrane