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Brain CYP distribution is extensiveacross the cortex, basal ganglia, hippocampus, substantia nigra, and other regionswith several isoforms (CYP1, CYP2, CYP3, and the brain-specific CYP46A1) expressed in astrocytes, neurons, and endothelial cells (Sjstedt et al., 2020)

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doi: 10.1016/j.jprot.2011.06.005 280 OlivieriFAlbertiniMCOrcianiMCekaACriccaMProcopioADet al

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This is documented in the Phase III data and is one of the reasons we screen baseline glucose metabolism at intake

They point out patients likely benefit from such programs, but being physically drained will impede ones ability to exercise