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It has been reported that PEI cationization facilitates protein transduction across the cell membrane and has been used in drug design to bypass bloodbrain barrier into the brain parenchyma via intranasal delivery (Futami et al , 2005, 2007

Concordantly, the fluorescence of gst-4::GFP reporter animals was induced on DB diet (Fig

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However, no difference in the p53 expression levels was observed in the presence of the proteasome inhibitor MG132, suggesting that proteasomal degradation of p53 is suppressed in MKRN1 knockout (KO) HT1080 cells (Extended Data Fig

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