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Notably, elevated concentrations of the dimeric macrocycles (above 100 nM) decreased the observed level of Met phosphorylation and this bell-shaped titration response was also observed with elevated concentrations of hHGF (above 5 nM)

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What they found: Prevention of age-related changes in gene expression , NMN-treated mice had an expression profile closer to young mice Restoration of mitochondrial function in multiple tissues Improvement of insulin sensitivity of 35 to 50 % Preserved muscle strength and endurance Preserved bone density Better vision (NMN-treated mice had a slower decline in ophthalmologic parameters) No serious adverse effects Why it matters: This is the most ambitious preclinical study of NMN/NAD+ in animal aging models

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