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Within one-carbon metabolism, serum folate is typically lowest during menses and rises into the luteal phase, while plasma homocysteine is lowest in the luteal phase and higher in the follicular/peri-ovulatory window, consistent with hormonally patterned shifts in methyl-group demand, oxidative stress, and inflammatory signaling across the cycle [143]

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Our institution (BRIN) obtained permission to collect samples based on a mandate from the Chief of Staff of the Presidency of the Republic of Indonesia to conduct a study on the kratom plant to obtain scientific evidence as a basis for policy-making by the Indonesian government regarding the status of the kratom plant

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58 This information is an important component to establish a diagnosis of IC/BPS, provides a baseline against which treatments can be evaluated, and is used to determine the appropriate level of entry into the treatment algorithm