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However, follow-up clinical studies are needed to further explore the clinical therapeutic effects and potential adverse reactions of these drugs

Gadolinium MRI Meta-analysis Group

Improved erastin analogs, such as piperazine erastin (PE) [24] and imidazole ketone erastin (IKE) [83] may be useful as in vivo probes of tumor susceptibility to ferroptosis

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Cancer cells may become resistant to platinum-based drugs through multiple mechanisms, including an increased ability to repair platinum-induced DNA damage, neutralization of platinum toxicity, and an increase in drug export (38)