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Although the specific causes of preeclampsia are not known, decreased intracellular concentrations of flavocoenzymes could cause mitochondrial dysfunction, increase oxidative stress, and interfere with nitric oxide release and thus blood vessel dilation

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TADs are the first-line drugs for CVS prophylaxis and have been shown to reduce the duration, severity, and frequency of episodes, as well as the number of emergency room visits and hospitalizations.90 Amitriptyline, the TAD of choice, is usually started at a low dose of 25mg and is gradually increased to a target dose of approximately 100mg at night in adults

UF wrote the first draft of the manuscript

doi:10.1016/j.heliyon.2023.e12963 Ikonomidis I, Katogiannis K, Chania C, et al