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AMPK is activated during the calcium switch-induced assembly of ZO-1, which facilitates tight junction assembly 81

More research needs to be done, but it does point to possible benefits from wheatgrass

H.LiC.LiuN.JiM

R.LeesA.JennerP.et al (2010)

First study assessing the impact of manipulating the gut microbiome on microglial responses and remyelination efficiency

Both of those, however, still involve Nrf2 activity