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When a DMC exists, the PI still has responsibilities A Data Monitoring Committee is not a substitute for site-level safety oversight

Goal: Drive substantial weight loss (up to ~20% of body weight) and stronger metabolic markers through dual GLP-1/GIP receptor agonism [2] [5]

Patel JJ, et al

Schjesvold F

Interestingly, IL-10, a potent anti-inflammatory cytokine that can prevent T1D, may also play a key role [89]

Subsequent membrane depolarization triggers the opening of voltagegated calcium channels, leading to a localized influx of Ca 2+ , The binding of calcium to synaptotagmin serves as the molecular trigger for the rapid fusion of synaptic vesicles and exocytotic release of dopamine into the synaptic cleft [193]