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N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis

Kroon, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

demonstrated that 100 mg/day of CoQ10 supplementation led to a significant increase in catalase (CAT) and glutathione peroxidase (GPx) activity in patients with T2DM [57]

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11 Interestingly, the antidepressant effects of ALC appeared most robust in older adults, suggesting age-related differences in mitochondrial or neurochemical pathways might mediate its psychotherapeutic actions

This finding is consistent with the lack of altered levels in plasma, though it cannot be assumed that plasma levels of a metabolite reflect its abundance in particular tissues and organs