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Expression of Thymosin Beta-4 has been observed to increase during early angiogenesis, and research suggests that the peptide may promote endothelial migration and vessel remodeling

(Lond.) 53 , 737754 (2021)

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High therapeutic dosages, frequent administration, significant presystemic metabolism (first-pass effect), enzymatic breakdown, organ toxicity, and limited brain availability owing to the blood-brain barrier (BBB) are some of the challenges that these therapies face [9]