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Most patients lose 1015% of their body weight in six months when they follow the plan

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In this 52-week trial, 47.2% of patients in the lorcaserin group lost at least 5% of their body weight, compared to 25% of patients in the placebo group [84]

When total B12 levels are difficult to interpret, measurement of holotranscobalamin (active B12), methylmalonic acid (MMA) , or homocysteine can provide a clearer picture of functional B12 status, though availability and interpretation vary (for example, MMA rises in renal impairment)