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Description

For details, see the Brewing section of our Green Tea Review

(3) Controlled release system: designing nanocarriers with gradual release capabilities can ensure sustained release of disulfiram, extending the drug's duration of action in the body and enhancing efficacy (Huo et al., 2017)

This manifests clinically with polyuria due to a nephrogenic diabetes insipidus -like effect on renal tubules, and mild hypertension secondary to calcium-induced vascular smooth muscle contraction

Leuco-methylthioninium bis (hydromethanesulfonate) is one such compound that has been reported to prevent tau aggregation and has subsequently been tested in cell lines and a transgenic mouse model of PD with encouraging results (Schwab et al