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This is especially important because most type 2 diabetes-associated variants lie in non-coding regions, complicating identification of causal variants, effector genes and relevant tissues

Mitochondrial damage exacerbates the susceptibility to seizures, creating a vicious circle that promotes further neuronal damage (140)

In a recent review, Tijms et al

When consumed, 2-DG is phosphorylated by hexokinase which then cannot be further processed and therefore is used as a glycolytic inhibitor

Exact number not reported but estimated from differential expression results or inferred from supplementary material

HanselBGiralPNobecourtEChantepieSBruckertEChapmanMJet alMetabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity