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Intriguingly, the -turn connecting strands 3 and 4 undergoes a large movement that closes the residues of the turn onto the THC molecule and brings Ala54 into hydrophobic contact distance, thereby closing off the FABP1 ligand entry portal, which is not observed in the palmitic acid-bound structure (Supplementary Fig
Caution is recommended in patients with a psychotic disorder (e.g., schizophrenia due to insufficient data
However, clinical evidence is still evolving, and individual outcomes vary
Chen F, Castranova V
Jinagal J, Gupta PC, Pilania RK, Ram J
Helps maintain energy metabolism and vitality
