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Because of anaphylaxis risk, intravenous B-12 administration is never recommended -intramuscular injection is the safe route

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doi:10.1016/j.amjoto.2012.06.009

KPVs strongest preclinical evidence is for oral delivery to gut tissue, where inflamed cells actively absorb it

So, going well over what the RDI dictates is non-negotiable, especially when it comes to seniors over 65 who will experience a decline in absorption rates as they age