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however, it failed to reach statistical significance ( P =0.1)

Studies using mouse models have confirmed that elevated HO-1 not only exacerbates the inflammatory response in macrophage-derived foam cells but also induces ferroptosis, resulting in a significantly increased plaque burden (77)

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A randomized, double-blind, placebo-controlled study published in the Journal of Alzheimer's Disease in 2020 found that intravenous NAD administration improved cognitive function and reduced oxidative stress in patients with Alzheimer's disease

Indeed, G6PD, by virtue of its importance in fundamental redox homeostasis and anabolic metabolism, plays a multifaceted, ubiquitous role in human physiology, including within immune responses