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The procedure briefly described as the image first was convered to an 8-bit gray-scale image then black-white inverted

The pivotal role of oxidative stress in the pathophysiology of cardiovascular-renal remodeling in kidney disease

A similar observation was made earlier where the alanine substitution of cysteines disrupted the disulfide bond at the proteinprotein interface [45]

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doi: 10.1186/s10020-022-00545-x 5 PereiraPRCarragetaDFOliveiraPFRodriguesAAlvesMGMonteiroMP

this advanced processing method was subsequently patented in 2014 under the trade name Eurosil 85 [2022]