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651 , A72 (2021)

Elevated serum cholesterol, liver damage, systemic inflammation, and hypoxic conditions can increase XO secretion via hepatic and other visceral pathways into the bloodstream and bind to the endothelial cell surface, initiating the overproduction of superoxide [77]

Statements Acknowledgments This work has been supported by grants from the Gleis Family Foundation, the University of California, Irvine Multiple Sclerosis Research Center (MSRC) and the National Multiple Sclerosis Foundation

MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility