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An acute toxic dose has not been established but it is known that vitamin B6 may cause neurotoxicity at a dose of 300 to 500 mg per day over time
However, studies of morphine and hydromorphone, both metabolized primarily by UGT, did not affect alcohol metabolism (281, 282)
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Rosenstock J, et al
10.1016/j.regpep.2009.11.012 72 TurkovicB.SikiricP.SeiwerthS.MiseS.AnicT.PetekM.et al (2004)
Likewise, BPC 157 consistently counteracted the induced general dysregulation of the NO-system, such as NO-system blockade
