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In normal physiology, the majority of circulating IGF-1 is bound to IGFBP-3, forming a large ternary complex with the acid-labile subunit that prevents rapid clearance and buffers free IGF-1 within a tightly controlled range

The American Diabetes Association recommends that all patients receive initial injection training from a healthcare professional and periodic technique review to maintain proper administration skills

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[PubMed: 10870111] 181