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These responses are mediated by the same ligand acting on the same binding site of the receptor, but the high-gain effect is nearly saturated even at concentrations which just begin to elicit the lower gain effect

This mechanical stimulation also stimulates cells to release growth factors, tensed muscle fibers to release, blood vessels to calm down (calming the reactive hyperemia), and more healing factors to be delivered to the injured area under normal vascular perfusion pressures

Interestingly, in cancer cell lines, significant telomere length extension also occurred, primarily through the activation of ALT (Alternative Lengthening of Telomeres) pathways, with only a minor increase in ALT activity observed in normal cells

Jan 2020;26(1):107-139