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To characterize HCAR1 signaling pathways, a study using a cell line designed to express human HCAR1 (CHO-K1) showed activation of extracellular signal-regulated kinases (ERK1/2) via HCAR1 in response to lactate and DHBA and sensitivity to the G i protein inhibitor pertussis toxin (Li et al., 2014)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Chuah SC, Moore PK, Zhu YZ

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

AMN is a form of adrenoleukodystrophy that affects the spinal cord and body (peripheral nerves), resulting in symptoms like muscle weakness, difficulty walking, and bladder dysfunction

Telomere dysfunction induces metabolic and mitochondrial compromise