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Next, we determined whether sg CBS could affect the TSS pathway activity and GSH generation at different cystine levels

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If we cannot rule out that other important putative residues in the areas covered by the chimeras M1, M3, M4 and M7, not expressed at the plasma membrane, could play a role in CS, we were able to identify the Glycine 1228 as a key residue for the stimulation of GSH efflux and CS, possibly located in a GSH gate

It exerts biological functions such as antioxidant and metabolic regulation through selenoproteins, which are key biomolecules