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doi:10.1016/j.ogc.2012.10.002

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PUM2 aggravates the neuroinflammation and brain damage induced by ischemiareperfusion through the SLC7A11-dependent inhibition of ferroptosis via suppressing the SIRT1

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This suggests that modulating ferroptosis in these 3 cell types plays an important role in depression (Figure 2)

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In summary, a large amount of clinical evidence shows that iron storage indicators, oxidative stress-related indicators, and ferroptosis-related genes are related to the occurrence of DM and can be used as targets for diagnosis and treatment

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Document progress to enable protocol adjustments at reassessment intervals

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