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Additionally, clinical trials involving natural products often face methodological issues such as inconsistent formulations, inter-individual variability among participants, and a need for large-scale studies to robustly assess therapeutic outcomes

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Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models

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Low M amounts of H 2 O 2 can rapidly oxidize the thiol residues on lipoic acid to SOH and deactivate Odh (Figure 2) (Applegate et al., 2 O 2 generating sulfinic (SO 2 H) and sulfonic acid (SO 3 H) which irreversibly deactivates the enzyme complex

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