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Too much NO leads to free radical production and eventual tissue damage

Macrophages in renal fibrosis
Unlike M1 macrophages, which stimulate T cell response thereby inducing an increase in IFN production in anti-CD3-activated PBMC/M1 co-culture, M2 macrophages exhibit a suppressive activity of T cell activity shown through IFN level decrease

Nervous System & Brain Health: Your dogs brain and nerves deserve the best care
Sep 17 2021;22(18)doi:10.3390/ijms221810043

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