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GSH is present in all mammalian cells in a constant state of metabolic recirculation (synthesis, degradation, and irreversible loss of GSH), its half-life is 4 days in human erythrocytes, 2 to 4 h in the cytosol of rat hepatic cells and 30 h in the mitochondrial lumen [40,80]

10.3389/fpsyt.2022.893309 73 ZhengG.YeB.ZhengY.XiongZ.XiaR.QiuP.et al

These effects are thought to improve recovery in tendons, ligaments, nerves, and digestive tissues

doi: 10.1016/j.chemosphere.2024.141513 4

Originally developed through groundbreaking research at Erasmus University Medical Center, FOXO4-DRI represents a targeted approach to cellular rejuvenation and has shown remarkable promise in preclinical studies for promoting healthspan and addressing age-related cellular dysfunction