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Figure 5 Systemic inflammation Systemic inflammation (225) and neuroinflammation (4547) are thought to play a major role in ME/CFS

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However, more research is needed in this area

60,61 CAUSES OF NAD+ DECLINE The above discussion demonstrates clear evidence for the role of NAD+ decline in the development of the hallmarks of aging in the skin, and there has been great interest in understanding the root causes of NAD+ decline to determine strategies to successfully restore cellular NAD+ levels

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