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The generation of mtROS from mitochondrial complex I also induces the NFAT complex, the subunit transcription factor c-Jun in AP-1, and further increases the expression of IL-2 and IL-4 (73, 81)

In the context of fibromyalgia, there is an excess of excitatory neurotransmitters (e.g., glutamate and substance P) [127,128] and a misfunction of the opioid receptors, leading to an enhanced perception of pain [126]

10.1007/s00432-014-1665-8 23 GongS.ChenJ.ZhengX.LuX.ChenM.LiJ.et al (2024)

1) and detailed in tables (Tables 1 and 2), highlighting research trends, dominant organ networks, and therapeutic opportunities

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