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doi: 10.1016/j.jnutbio.2006.12.003
NADPH is used by glutathione reductase to regenerate GSH from GSSG, thus they work hand in hand
If the sulfation pathway is defective, as has been shown in autism, and/or there is impaired glucuronidation, acetaminophen will be increasingly converted to the alternative metabolic routes, increasing production of its more toxic compounds NAPQI and AM404
doi: 10.1016/0006-291X(92)91343-O
p53 is known to have a dual role as a suppressor or promoter of ferroptosis (53,92)
In contrast to NFT, they required no activation by cellular reductases (Fig
