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Since the livers of PXB mice are replaced by human hepatocytes, these mice have the human hepatic ability to metabolize and excrete xenobiotic compounds

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Busulfan is converted to a glutathione S -conjugate (l--glutamyl--( S -tetrahydrothiophenium)-l-alanylglycine) by direct interaction with GSH (Ritter et al., 1999) and enzymatic catalysis by GSTs, especially GSTA1-1 (Czerwinski et al., 1996, Gibbs et al., 1996, Ritter et al., 1999, Ritter et al., 2002)

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