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doi: 10.3389/fneur.2019.00345 274 SahP

A provider-directed plan often starts with an introductory concentration, such as 1% to 2%, once daily to assess tolerance

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Other drugs that affect incretin function are the DPP-IV inhibitors (eg, sitagliptin [Januvia])

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Because GLP-1 receptors saturate, layering a second GLP-1 agonist yields diminishing returns while side effects continue to scale