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10.1186/s40659-018-0157-8 Summary Keywords berberine, renal diseases, inflammation, oxidative stress, apoptosis Citation Fan Z, Wei X, Zhu X, Yang K, Tian L, Wang X, Du Y and Yang L (2025) Unveiling the therapeutic potential of berberine: its therapeutic role and molecular mechanisms in kidney diseases

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In this context, it is noteworthy that ibuprofen is known to reduce inflammation via inhibition of COX-2, but also via modulation of the angiotensin pathway by shifting the ACE/ACE-2 (angiotensin converting enzyme) receptor ratio towards ACE-2 (119, 120) (discussed in detail in Section 4.2)

[DOI] [PubMed] [Google Scholar] 92.Kensler T.W., Chen J.G., Egner P.A., Fahey J.W., Jacobson L.P., Stephenson K.K., Ye L., Coady J.L., Wang J.B., Wu Y., et al

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