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These factors induce oxidative stress, endoplasmic reticulum (ER) stress, or DAMPs release, resulting in inflammation, immune dysregulation, and melanocyte destruction ( NLRP1 and IFIH , may predispose individuals to activate innate immune pathways more readily
Biasi F, Tessitore L, Zanetti D, et al
doi: 10.1124/mol.112.082602 104
The Janus kinase 2 and c-Jun N-terminal kinase pathways regulate HIF-1 regulation via adenosine monophosphate-activated protein kinase (AMPK) in response to H 2 O 2
The antioxidant system in body can reduce the levels of O 2 and HO, decreasing OH production and inhibiting NETosis [245]
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