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Chronic hyperglycemia damages the small blood vessels supplying peripheral nerves (vasa nervorum), creating ischemic nerve injury that begins in the longest nerves first those reaching the toes and gradually spreads proximally in a stocking-glove distribution

International union of basic and clinical pharmacology

Brzozowski T, Konturek PC, Pajdo R, et al

How Vitamin B12 helps the body Vitamin B12 Deficiency Vitamin B12 deficiency occurs when the body lacks an adequate amount of vitamin B12 to maintain optimal health and functioning

Cis-DDPs well-known nephrotoxicity, indeed, has been proved to be related to his GSH-conjugated compounds that, being metabolized to cysteine S-conjugate by cysteine S-conjugate -lyase activity (highly expressed in renal cells), is mainly responsible for proximal tubule cell damage [114]