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For example, DNA demethylation in an oncogene promoter region activates oncogene expression, leading to the development of resistance (30, 41)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Lenz M, Galanis C, Mller-Dahlhaus F, Opitz A, Wierenga CJ, Szab G, et al

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Its structure is shown below, and the known pKa values of its ionizable groups are highlighted
