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The CYP2R1 gene is located on chromosome 11p15.2 and is composed of 9 exons that generate six alternatively spliced mRNAs encoding three distinct protein isoforms

GGT is present in several organs, including the kidneys, pancreas, and heart, which is why an isolated elevation can require a wider review instead of an automatic assumption of liver disease (medical policy summary on GGT testing in adults)

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To determine whether TGF- or BMP signaling modulation recapitulates the KO phenotype, we treated WT DE cells with activin A (AA) and/or BMP4 to activate the TGF- and BMP pathways, respectively