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2 Low back pain and intervertebral disc degeneration Low back pain (LBP) is one of the most common clinical symptoms, significantly impacting individuals across broad populations (Hartvigsen et al., 2018

The indirect costs of IC/BPS, including time away from work and lost productivity while working, are particularly significant since the condition primarily affects working age adults, and especially women aged 25-50 years

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However, increased exposure was seen with UGT1A9 substrates and decreased exposure with CYP2B6 substrates when co-administered with cannabidiol

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