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Interestingly, a drug that selectively inhibits serotonin reuptake (fluoxetine) and one that blocks both serotonin and norepinephrine reuptake (milnacipran) were both found to be effective in reducing alcohol self-administration in dependent rats (Simon OBrien et al., 2011), while a novel triple monoamine uptake inhibitor was reported to reduce alcohol intake in rats with a genetic predisposition for high alcohol preference (Yang et al., 2012)