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Opioid tolerance and dependence: An inevitable consequence of chronic treatment
White peony extract: A 2014 study showed substantial clinical improvement, along with a significant drop in inflammatory cytokines, in 32% of patients treated exclusively with peony glucosides

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This rapid effect on vessel structure occurs before gene expression changes fully manifest, suggesting direct molecular interactions alongside the longer-term transcriptional effects

10.1016/j.copbio.2012.08.005 [DOI] [PubMed] [Google Scholar] McGuire S
