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FDA-approved GLP-1 peptides such as semaglutide and tirzepatide bind to the GLP-1 receptor, the same receptor a natural gut hormone uses to reduce hunger, slow digestion, and help regulate blood sugar

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Results vary widely between individuals, and patients should approach treatment with realistic expectations about gradual, modest outcomes

The drug release at pH 5.2 was around 90% due to protonation of amino and benzimidazole groups, which caused dissociation of the complexes

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