igf 1 lr3 mixing and dosage Recombinant human IGF-1 protein (Qk041) igf 1 lr3 mixing and

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doi: 10.1007/s13238-016-0245-x 36 ZhangQZengXGuoJWangX

List of abbreviations ACR American College of Rheumatology BMI body mass index BNF British National Formulary CI confidence interval COX cyclo-oxygenase CRD Centre for Reviews and Dissemination EVPI expected value of perfect information FDA Food and Drug Administration GAIT Glucosamine/chondroitin Arthritis Intervention Trial ICER incremental cost-effectiveness ratio IL interleukin iNOS inducible nitric oxide synthase INR international normalised ratio JOA Japan Orthopaedic Association MCID minimal clinically important difference MHRA Medicines and Healthcare Products Regulatory Agency MMP matrix metalloproteinase MRI magnetic resonance imaging mRNA messenger ribonucleic acid NCCCC National Collaborative Centre for Chronic Conditions NICE National Institute for Health and Clinical Excellence NO nitric oxide NSAID non-steroidal anti-inflammatory drug OA osteoarthritis OARSI Osteoarthritis Research Society International OMERACT outcome measurement in clinical trials PGE2 prostaglandin E2 PPP purchasing power parity QALY quality-adjusted life-year QoL quality of life QUOROM quality of reporting of meta-analyses RCT randomised controlled trial RR relative risk SD standard deviation SE standard error SF-36 36-item Short Form General Health Survey TKR total knee replacement TNF tumour necrosis factor VAS visual analogue scale WHO World Health Organization WOMAC Western Ontario and McMaster Universities osteoarthritis index All abbreviations that have been used in this report are listed here unless the abbreviation is well known (e.g