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In mammalian cells, stress conditions lead to the upregulation of CHAC1 through the action of ATF4

Hydroperoxides can be reduced to hydroxy groups to produce 13( S )-HODE in human, 65,182 and 9( S )-HODE in mice

Cortisol synergizing with endoplasmic reticulum stress induces regulatory T-cell dysfunction

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PMID 21523732

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