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The high dependence of mitochondria on iron for metabolic processes and haem and Fe-S cluster synthesis suggests that iron deficiency profoundly affects mitochondrial processes and extra-mitochondrial pathways that rely on haem, Fe-S cluster cofactors, or mitochondrially derived metabolites produced by iron-dependent processes (e.g., -KG for 2-ODGG enzymes)

Scireq) as previously described (32, 33)

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doi: 10.1038/s41598-020-67288-9

Furthermore, statistically significant positive correlations were found between paraoxanase-FEV1 (r=0.835), paraoxanase-FVC (r=0.807), and paraoxanase-DLCO (r=0.905) ( Supplementary Figure S1-Supplementary File )

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