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As oligodendrocytes are the primary iron-containing cells in the brain and play a crucial role in maintaining iron homeostasis for myelin synthesis through the expression of transferrin and ferritin [182], their degeneration can release excess iron into the local environment, potentially exacerbating oxidative damage and ferroptosis

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To view a copy of this licence, visit About this article Cite this article Lenzen, S., Lushchak, V.I

These techniques allow for the delivery of high doses to the tumor while sparing surrounding normal tissues, including the brain [92, 93]

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Mass spectrometry (MS): LC-MS and LC-MS/MS provide the highest specificity and sensitivity for glutathione analysis