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This tolerance development explains why side effects are most prominent during treatment initiation and dose escalation but decline substantially with continued use

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Follow-up imaging at six to twelve weeks can help assess whether conservative management is working

Comprehensive medical assessment before initiating treatment remains essential, as clinical trial populations never fully represent the diversity of health conditions encountered in practice

Also, CAR-T cells directed to PDPN by a construct composed of NZ-1-based single-chain variable fragments and CD28, 4-1BB and CD3 intracellular domains have shown good efficiency against glioma cells both in vitro and in vivo glioma xenografts (277)

This non-targeted approach enables large-scale complex sample quantification